Jasper's Basic Mechanisms of the Epilepsies, Fifth Edition
Edited by Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Annamaria Vezzani and Antonio V. Delgado-Escueta
Published by Oxford University Press
Hardcover
Published: 07 May 2024
1752 Pages | 204 illustrations
7 x 10 inches
ISBN: 9780197549469
Open Access E-book Versions
- Oxford Academic: https://academic.oup.com/book/57972
- NCBI Bookshelf of the National Library of Medicine: https://preview.ncbi.nlm.nih.gov/books/prevqa/NBK365457/
Text on Jacket Cover
Jasper’s Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, Jasper’s Basic Mechanisms of the Epilepsies has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student as a clinical reference and for board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 80 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.
Jasper’s Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, Jasper’s Basic Mechanisms of the Epilepsies has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student as a clinical reference and for board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 80 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.
Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition
Edited by Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen and Antonio V. Delgado-Escueta
Editorial Advisory Board: Giuseppe Biagini, Amy R. Brooks-Kayal, Wolfgang Loscher, Helen E. Scharfman, Philip A. Schwartzkroin, John W. Swann, and Annamaria Vezzani
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a “better understanding of the epilepsies and seek more rational methods of their prevention and treatment.” Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind—assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper’s BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the “bible” of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain structures that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.
Hardcover version of the book is published by Oxford University Press
ISBN-10: 0199746540 | ISBN-13: 978-0199746545 | Edition: 4 |
Online version of the book is available on Bookshelf, a service of the National Center for Biotechnology Information, NIH.
Click on image to access online version. |
Book Review by Carl Stafstrom
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Editors Met in Malibu to Finalize the Book
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Neurotransmitter Actions in the Vertebrate Nervous System
Edited by Michael A. Rogawski and Jeffery L. Barker
Edited by Michael A. Rogawski and Jeffery L. Barker
Intercellular communication via bioactive substances occurs in virtually all multicellular systems. Chemical neurotransmission in the vertebrate nervous system represents a form of signaling of this type. The biology of chemical neurotransmission is complex, involving transmitter synthesis, transport, and release by the presynaptic neuron; signal generation in the target tissue; and mechanisms for termination of the response. The focus of this book is on one aspect of this scheme: the diverse electrophysiological effects induced by different neurotransmitters on targets cells. In recent years, astonishing progress has been made in elucidating the specific physiological signals mediated by neurotransmitters in the vertebrate nervous system, yet, in our view, this has not been adequately recognized, perhaps because the new concepts have yet to filter into neuroscience textbooks. Nevertheless, the principles of neurotransmitter action are critical to advances in many areas of neuroscience, including molecular neurobiology, neurochemistry, neuropharmacology, physiological psychology, and clinical neuroscience. It was the need for a sourcebook that prompted us to engage a group of neurophysiologists to prepare the chapters in this volume. However, there was an additional reason for this book: more and more it seemed that the field, if not yet having reached maturity, at least was approaching adolescence, with strengths in some areas and healthy conflicts in others. At this stage of development a textbook can help to define a field, clarify problems to be resolved, and identify areas for future investigation.
Publisher: Springer, Boston, MA; Print ISBN 978-1-4684-4963-1; Online ISBN 978-1-4684-4961-7
DOI http://doi.org/10.1007/978-1-4684-4961-7
Softcover reprint of the original 1st ed. 1985, XXVIII, 511 p. and e-book: http://www.springer.com/us/book/9781468449631